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Novel NLR Proteins and Their Functions in Immune Privilige and Tolerance

The human Nod-like Receptor (NLR) family has been discovered within the last decade and studies on its 23 members have been rapidly accumulating. Among the members with defined functions NOD1 and NOD2 have been shown to detect bacteria specific macromolecular components, namely parts of peptidoglycan, once they have reached the cytoplasm.